Pair Name	Pterostilbene, Vorinostat
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Gene Regulation	Down-regulation	Expression	HIF1A	hsa3091
	Down-regulation	Expression	IL1B	hsa3553
	Down-regulation	Expression	MTA1	hsa9112
	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	LNCaP	Prostate carcinoma	Homo sapiens (Human)	CVCL_0395
In Vivo Model	Female C57BL/6J mouse homozygous with "floxed" allele of Pten gene were used in this study.
Result	Our study provides preclinical evidence that Pter/SAHA combination treatment inhibits MTA1/HIF-1α tumor-promoting signaling in PCa. The beneficial outcome of combinatorial strategy using a natural agent and an approved drug for higher efficacy and less toxicity supports further development of MTA1-targeted therapies in PCa.